Propylene glycol(PG/MPG) ,CAS :57-55-6

Propylene glycol has good solubility and less toxicity and irritation, and is widely used as solvents, extraction solvents and preservatives for injections (eg. intramuscular injections, intravenous injections) and non-injectable pharmaceutical preparations (such as oral liquid, ophthalmic preparations, otic preparations, dental preparations, rectovaginal preparations, transdermal preparations, etc.). It is better than glycerol solvent and can dissolve many substances such as corticosteroids (sex hormone), chloramphenicol, sulfonamides, barbiturate, reserpine, quinidine, corticosterone acetate, tetrahydropalmatine sulfate, mechlorethamine hydrochloride, vitamin A, vitamin D, many volatile oils, most of the alkaloids and many local anesthetics.
Propylene glycol is similar to ethanol when used as a bacteriostatic agent, and its efficacy to inhibit mold is similar to glycerin and is slightly lower than that of ethanol. Propylene glycol is commonly used as a plasticizer for the aqueous film coating materials. Its mixture with equal amounts of water can delay the hydrolysis of certain drugs, and increase the stability of the preparation product. It is used as an antimicrobial preservative in 15 percent to 30 percent propylene glycol solution and semi-solid formulation, as humectants in about 15 percent propylene glycol topical formulation, and as solvent and co-solvent in 10 percent to 30 percent propylene glycol aerosol solvent, 10 percent to 25 percent propylene glycol oral solution, 10 percent to 60 percent injectable formulation and 5 percent to 80 percent topical formulation.
Stability and storage condition It is very stable at room temperature, but is oxidized when left open at high temperatures (above 280 degree ); has a chemical stability after mixing with 95 percent ethanol or water; can be sterilized by autoclaving or sterile filtration. Propylene glycol has hygroscopicity, and should be positioned at cool and dry place and stored in dark airtight container.

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